Research

WHAT WE DO

Electrophysiology

Flow Cytometry

Immunocytochemistry

Molecular Biology

Biochemistry

Bioinformatics

PUBLICATIONS

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α₂δ Subunits, and Enables Calcium Current Enhancement

Ivan Kadurin, Shehrazade Dahimene, Karen M Page, Joseph I J Ellaway, Kanchan Chaggar, Linda Troeberg, Hideaki Nagase, Annette C Dolphin

Function, Volume 3, Issue 3, 2022, zqac013
https://doi.org/10.1093/function/zqac013

The α₂δ-like protein Cachd1 increases N-type calcium currents and cell surface expression and competes with α₂δ.

Shehrazade Dahimene, Karen M Page, Ivan Kadurin, Laurent Ferron, Dominique Y Ho, Garreth T Powell, Wendy S Pratt, Stephen W Wilson, Annette C Dolphin

Cell Reports, Volume 25, Issue 6, 2018, 1610-1621.e5
https://doi.org/10.1016/j.celrep.2018.10.033

Proteolytic maturation of α₂δ controls the probability of synaptic vesicular release

Laurent Ferron, Ivan Kadurin, Annette C Dolphin

eLife, 2018, e37507
https://doi.org/10.7554/eLife.37507

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α₂δ-1 subunit

Ivan Kadurin, Simon W Rothwell, Beatrice Lana, Manuela Nieto-Rostro, Annette C Dolphin

Scientific Reports 7, 2017, 43802
https://doi.org/10.1038/srep43802

Proteolytic maturation of α₂δ is key to activation and neuronal trafficking of latent calcium channels

Ivan Kadurin, Laurent Ferron, Simon W Rothwell, James O Meyer, Leon R Douglas, Claudia S Bauer, Beatrice Lana, Wojciech Margas, Orpheas Alexopoulos, Manuela Nieto-Rostro, Wendy S Pratt, Annette C Dolphin

eLife, 2016, 5, e21143
https://doi.org/10.7554/eLife.21143

Functional exofacially tagged N-type calcium channels elucidate the interaction with α₂δ-1 subunits

John S Cassidy, Laurent Ferron, Ivan Kadurin, Wendy S Pratt, Annette C Dolphin

PNAS, Volume 111, Issue 24, 2014, 8979- 8984
https://doi.org/10.1073/pnas.1403731111

Calcium currents are enhanced by α₂δ-1 lacking its membrane anchor

Ivan Kadurin, Anita Alvarez-Laviada, Shu Fun Josephine Ng, Ryan Walker-Gray, Marianna D'Arco, Michael G Fadel, Wendy S Pratt, Annette C Dolphin

Journal of Biological Chemistry, Volume 287, Issue 40, 2012, 33554– 33566
https://doi.org/10.1074/jbc.M112.378554

Presynaptic HCN1 channels regulate Ca_V3.2 activity and neurotransmission at select cortical synapses

Zhuo Huang, Rafael Lujan, Ivan Kadurin, Victor N Uebele, John J Renger, Annette C Dolphin & Mala M Shah

Nature Neuroscience, Volume 14, Issue 4, 2011, 478–486
https://doi.org/10.1038/nn.2757

The α₂δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

Anthony Davies, Ivan Kadurin, Anita Alvarez-Laviada, Leon Douglas, Manuela Nieto-Rostro, Claudia S Bauer, Wendy S Pratt, and Annette C Dolphin

PNAS, Volume 107, Issue 4, 2010, 1654–1659
https://doi.org/10.1073/pnas.0908735107

A single conserved proline residue determines the membrane topology of stomatin

Ivan Kadurin, Stephan Huber, Stefan Gründer

Biochemical Journal, Volume 418, Issue 3, 2009, 587–594
https://doi.org/10.1042/BJ20081662

N-linked glycans influence expression of Acid-Sensing Ion Channel (ASIC) 1a and 1b on the cell surface

Ivan Kadurin, Andjelko Golubovic, Lilia Leisle, Hermann Schindelin, Stefan Gründer

Biochemical Journal, Volume 412, Issue 3, 2008, 469–475
https://doi.org/10.1042/BJ20071614

FUNDING

MRC: New Investigator Research Grant (2022–2025)
BHF Project grant (2019–2021)

RESEARCH

KADURIN LAB — QMUL

WHAT WE DO

Electrophysiology

Flow Cytometry

Immunocytochemistry

Molecular Biology

Biochemistry

Bioinformatics

PUBLICATIONS

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α₂δ Subunits, and Enables Calcium Current Enhancement

The α₂δ-like protein Cachd1 increases N-type calcium currents and cell surface expression and competes with α₂δ.

Proteolytic maturation of α₂δ controls the probability of synaptic vesicular release

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α₂δ-1 subunit

Proteolytic maturation of α₂δ is key to activation and neuronal trafficking of latent calcium channels

Functional exofacially tagged N-type calcium channels elucidate the interaction with α₂δ-1 subunits

Calcium currents are enhanced by α₂δ-1 lacking its membrane anchor

Presynaptic HCN1 channels regulate Ca_V3.2 activity and neurotransmission at select cortical synapses

The α₂δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

A single conserved proline residue determines the membrane topology of stomatin

N-linked glycans influence expression of Acid-Sensing Ion Channel (ASIC) 1a and 1b on the cell surface

FUNDING

RESEARCH

KADURIN LAB — QMUL

WHAT WE DO

Electrophysiology

Flow Cytometry

Immunocytochemistry

Molecular Biology

Biochemistry

Bioinformatics

PUBLICATIONS

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current Enhancement

The α2δ-like protein Cachd1 increases N-type calcium currents and cell surface expression and competes with α2δ.

Proteolytic maturation of α2δ controls the probability of synaptic vesicular release

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit

Proteolytic maturation of α2δ is key to activation and neuronal trafficking of latent calcium channels

Functional exofacially tagged N-type calcium channels elucidate the interaction with α2δ-1 subunits

Calcium currents are enhanced by α2δ-1 lacking its membrane anchor

Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

The α2δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

A single conserved proline residue determines the membrane topology of stomatin

N-linked glycans influence expression of Acid-Sensing Ion Channel (ASIC) 1a and 1b on the cell surface

FUNDING

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α₂δ Subunits, and Enables Calcium Current Enhancement

The α₂δ-like protein Cachd1 increases N-type calcium currents and cell surface expression and competes with α₂δ.

Proteolytic maturation of α₂δ controls the probability of synaptic vesicular release

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α₂δ-1 subunit

Proteolytic maturation of α₂δ is key to activation and neuronal trafficking of latent calcium channels

Functional exofacially tagged N-type calcium channels elucidate the interaction with α₂δ-1 subunits

Calcium currents are enhanced by α₂δ-1 lacking its membrane anchor

Presynaptic HCN1 channels regulate Ca_V3.2 activity and neurotransmission at select cortical synapses

The α₂δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function